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Figure 1: Single-cell analysis of in vitro model of fatty liver disease and non-alcoholic steatohepatitis, revealing distinct and co-existing metabolic states of cells. Figure 2: Artistic overlay of microscopy image of hepatocytes with the single-cell intensities of a particular intracellular metabolite. The Alexandrov team develops experimental and computational methods and tools for the novel fields of spatial and single-cell metabolomics. Metabolomics, the field of science and technology concerned with small molecules, metabolites, and lipids, promises to advance our understanding of cell biology, physiology, and medicine. In recent years, metabolomics has progressed from cataloguing chemical structures to answering complex biomedical questions.
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